Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti‐inflammatory phenotype through STAT3 pathway

2019187 citationsJournal Articlegold Open Access

Authors

Zongjian Liu · China Rehabilitation Research Center

Yuanyuan Ran · Capital Medical University

Shuyan Qie · Capital Medical University

Weijun Gong · Capital Medical University

Fuhai Gao · China Rehabilitation Research Center

Zitong Ding · Capital Medical University

Jianing Xi ·

Abstract

Melatonin treatment ameliorates brain damage at least partially through shifting microglia phenotype from pro-inflammatory to anti-inflammatory polarity in a STAT3-dependent manner.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Circadian rhythm and melatonin Neurological Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: CNS Neuroscience & Therapeutics

Volume 25, Issue 12, pp. 1353-1362

DOI: 10.1111/cns.13261

Field-Weighted Citation Impact: 8.86