Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

2019197 citationsJournal Articlegold Open Access

Authors

Weilin Xu · Second Affiliated Hospital of Zhejiang University

Tao Li · Second Affiliated Hospital of Zhejiang University

Liansheng Gao · Second Affiliated Hospital of Zhejiang University

Jingwei Zheng · Second Affiliated Hospital of Zhejiang University

Jun Yan · Tumor Hospital of Guangxi Medical University

Jianmin Zhang · Second Affiliated Hospital of Zhejiang University

Abstract

Exogenous apelin-13 binding to APJ attenuates early brain injury by reducing ER stress-mediated oxidative stress and neuroinflammation, which is at least partly mediated by the AMPK/TXNIP/NLRP3 signaling pathway.

Topics & Keywords

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Journal of Neuroinflammation

Volume 16, Issue 1, pp. 247-247

DOI: 10.1186/s12974-019-1620-3

Field-Weighted Citation Impact: 17.96