Blocking CD47 efficiently potentiated therapeutic effects of anti-angiogenic therapy in non-small cell lung cancer

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Authors

Xuyao Zhang · Fudan University

Yichen Wang · Fudan University

Jiajun Fan · Fudan University

Wei Chen · Fudan University

Jingyun Luan · Fudan University

Xiaobin Mei · Second Military Medical University

Shaofei Wang · Fudan University

Abstract

Our research provided evidence that CD47 blockade could sensitize NSCLC to anti-angiogenic therapy and potentiate its anti-tumor effects by enhancing macrophage infiltration and tumor cell destruction, providing novel therapeutics for NSCLC by disrupting CD47/SIRPα interaction and angiogenetic axis.

Topics & Keywords

Phagocytosis and Immune Regulation Immune cells in cancer Immunotherapy and Immune Responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal for ImmunoTherapy of Cancer

Volume 7, Issue 1, pp. 346-346

DOI: 10.1186/s40425-019-0812-9

Field-Weighted Citation Impact: 3.76