Changes in m6A RNA Methylation Contribute to Heart Failure Progression by Modulating Translation

2019318 citationsJournal Articlehybrid Open Access

Authors

Tea Berulava · German Center for Neurodegenerative Diseases

Eric Buchholz · German Centre for Cardiovascular Research

Elerdashvili Vakhtang · German Center for Neurodegenerative Diseases

Tonatiuh Peña · German Center for Neurodegenerative Diseases

Rezaul Islam · German Center for Neurodegenerative Diseases

Dawid Lbik · German Centre for Cardiovascular Research

Belal A. Mohamed

Abstract

We could show that m6A landscape is altered in heart hypertrophy and heart failure. m6A RNA methylation changes lead to changes in protein abundance, unconnected to mRNA levels. This uncovers a new transcription-independent mechanisms of translation regulation. Therefore, our data suggest that modulation of epitranscriptomic processes such as m6A methylation might be an interesting target for therapeutic interventions.

Topics & Keywords

RNA modifications and cancer HVDC Systems and Fault Protection Cancer-related gene regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Journal of Heart Failure

Volume 22, Issue 1, pp. 54-66

DOI: 10.1002/ejhf.1672

Field-Weighted Citation Impact: 12.33