LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells

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Authors

Yi Cui · National Health and Family Planning Commission

Yanyun Yin · Chinese Academy of Sciences

Zhifeng Xiao · Institute of Genetics and Developmental Biology

Yannan Zhao · Chinese Academy of Sciences

Bing Chen · Chinese Academy of Sciences

Bin Yang · Institute of Genetics and Developmental Biology

Xu Bai

Abstract

Our results confirm the therapeutic effectiveness of miR-124 on the functional recovery of injured spinal cord, supporting the rationale and feasibility of miR-124 for spinal cord injury treatment in future clinical therapy. Furthermore, we concluded that the miR-124-Neat1-Wnt/β-catenin signaling axis is involved in regulating the cell function of SC-NPCs, and this may offer novel therapeutic avenues for future treatment of SCI.

Topics & Keywords

Spinal Cord Injury Research Cancer-related molecular mechanisms research MicroRNA in disease regulation

Publication Details

Published in: Stem Cell Research & Therapy

Volume 10, Issue 1, pp. 400-400

DOI: 10.1186/s13287-019-1487-3

Field-Weighted Citation Impact: 7.68

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LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells

Authors

Abstract

Topics & Keywords

Publication Details