DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways

201949 citationsJournal Articlegold Open Access

Authors

Faiza Noreen · SIB Swiss Institute of Bioinformatics

Taya Küng · University of Basel

Luigi Tornillo · University Hospital of Basel

Hannah Parker · University of Zurich

Miguel G. Silva · Technical University of Munich

Stefan Weis · University of Basel

Giancarlo Marra ·

Abstract

Hence, while age-lifestyle-driven hypermethylation occurs generally in colon carcinogenesis, BRAF<sup>V600E</sup>-driven hypermethylation is specific for the "serrated" pathway. This knowledge will advance the use of epigenetic biomarkers to assess subgroup-specific CC risk and disease progression.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Epigenetics

Volume 11, Issue 1, pp. 196-196

DOI: 10.1186/s13148-019-0791-1

Field-Weighted Citation Impact: 3.34