Rapidly progressive and fatal case of extragenital cutaneous epithelioid angiosarcoma with visceral involvement

Cutaneous angiosarcomas (CASs) are aggressive malignancies with a poor prognosis. Although rare, most cases are seen 1) on the head and neck of elderly men, 2) in irradiated skin after therapy for breast carcinoma, and 3) in the setting of long-standing lymphedema (Stewart-Treves syndrome). Only 5 cases of cutaneous external genital CAS have been reported, usually in the setting of pelvic radiation for gynecologic malignancies.1 Here, we describe a case of rapidly progressive and fatal inguinal epithelioid CAS with visceral involvement.