TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus

202078 citationsJournal Articlegold Open Access

Authors

Jiawei Zhang · Shanghai Jiao Tong University

Yu Liu · Shanghai Eighth People Hospital

Yaling Zheng · Shanghai Jiao Tong University

Yan Luo · Shanghai Jiao Tong University

Yu Du · Shanghai Sixth People's Hospital

Yao Zhao · Shanghai Jiao Tong University

Jian Guan ·

Abstract

These results suggest that TREM-2 negatively regulates p38 MAPK-mediated inflammatory response when DM was synergistically superimposed on CCH and highlight the importance of TREM-2 as a potential target of immune regulation in DM and CCH.

Topics & Keywords

Inflammation biomarkers and pathways Neurological Disease Mechanisms and Treatments Neuroinflammation and Neurodegeneration Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 17, Issue 1, pp. 2-2

DOI: 10.1186/s12974-019-1688-9

Field-Weighted Citation Impact: 4.15