TGF-β2 silencing to target biliary-derived liver diseases

202043 citationsJournal Articlehybrid Open Access

Authors

Anne Dropmann · Heidelberg University

Steven Dooley · Heidelberg University

Bedair Dewidar · Tanta University

Seddik Hammad · South Valley University

T. Dediulia · Heidelberg University

Julia Werle · Heidelberg University

Vanessa Hartwig ·

Abstract

Taken together, our data suggest a new mechanistic explanation for amelioration of fibrogenesis by TGF-β2 silencing and provide a direct rationale for TGF-β2-directed drug development.

Topics & Keywords

Liver physiology and pathology Pediatric Hepatobiliary Diseases and Treatments Liver Diseases and Immunity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 69, Issue 9, pp. 1677-1690

DOI: 10.1136/gutjnl-2019-319091

Field-Weighted Citation Impact: 3.69