Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2

202073 citationsJournal Articlegold Open Access

Authors

Lei Zhou · Shandong University

Changsheng Yang · Shandong University

Ning Zhang · Jinan City People's Hospital

Xin Zhang · Shandong First Medical University

Tingbao Zhao · Shandong University

Jinming Yu · Shandong University

Abstract

Overall, our study revealed that METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosarcoma treatment.

Topics & Keywords

RNA modifications and cancer Cancer-related gene regulation Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Biomedicine & Pharmacotherapy

Volume 125, pp. 109964-109964

DOI: 10.1016/j.biopha.2020.109964

Field-Weighted Citation Impact: 4.84