Neonatal hypoxia-ischemia in rat elicits a region-specific neurotrophic response in SVZ microglia

202029 citationsJournal Articlegold Open Access

Authors

Urs Fisch · University Hospital of Basel

Catherine Brégère · University Hospital of Basel

Florian Geier · SIB Swiss Institute of Bioinformatics

Laurie Chicha · University Hospital of Basel

Raphaël Guzman · University Hospital of Basel

Abstract

Microglia are an inherent cellular component of the early postnatal SVZ and undergo developmental changes that are affected on many aspects by neonatal HI injury. Our results demonstrate that early postnatal SVZ microglia are sensitive to HI injury and display a long-lasting region-specific response including neurotrophic features.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Neonatal and fetal brain pathology Neurogenesis and neuroplasticity mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 17, Issue 1, pp. 26-26

DOI: 10.1186/s12974-020-1706-y

Field-Weighted Citation Impact: 1.68