Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

2020275 citationsJournal Articlegreen Open Access

Authors

Ajit Magadum · MACOM (United States)

Neha Singh · MACOM (United States)

Ann Kurian · Anna Needs Neuroblastoma Answers

Irsa Munir · MACOM (United States)

Talha Mehmood · Mahindra and Mahindra Limited (India)

Kemar Brown · MACOM (United States)

Mohammad Tofael Kabir Sharkar ·

Abstract

We demonstrate that Pkm2 is an important intrinsic regulator of the cardiomyocyte cell cycle and oxidative stress, and highlight its therapeutic potential using cardiomyocyte-specific Pkm2 modified RNA as a gene delivery platform.

Topics & Keywords

Congenital heart defects research Cardiac Fibrosis and Remodeling Cardiac Ischemia and Reperfusion

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 141, Issue 15, pp. 1249-1265

DOI: 10.1161/circulationaha.119.043067

Field-Weighted Citation Impact: 11.46