Redefinition of familial intestinal gastric cancer: clinical and genetic perspectives

202041 citationsJournal Articlebronze Open Access

Authors

Joana Carvalho · Universidade do Porto

Patrícia Oliveira · Universidade do Porto

Janine Senz · BC Cancer Agency

Celina São José · Universidade do Porto

Samantha Hansford · BC Cancer Agency

Sara Pinto Teles · Universidade do Porto

Marta Ferreira ·

Abstract

This study proposed the first data-driven testing criteria for FIGC families, and supported FIGC as a genetically determined, likely polygenic, gastric cancer-predisposing disease, with earlier onset and distinct from patients with SIGC at the germline and somatic levels.

Topics & Keywords

Genetic factors in colorectal cancer Digestive system and related health Helicobacter pylori-related gastroenterology studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Medical Genetics

Volume 58, Issue 1, pp. 1-11

DOI: 10.1136/jmedgenet-2019-106346

Field-Weighted Citation Impact: 3.33