Malignant transformation of oral leukoplakia is associated with macrophage polarization

202083 citationsJournal Articlegold Open Access

Authors

Manuel Weber · Friedrich-Alexander-Universität Erlangen-Nürnberg

Falk Wehrhan · Friedrich-Alexander-Universität Erlangen-Nürnberg

Christoph Baran · Friedrich-Alexander-Universität Erlangen-Nürnberg

Abbas Agaimy · Friedrich-Alexander-Universität Erlangen-Nürnberg

Maike Büttner‐Herold · Friedrich-Alexander-Universität Erlangen-Nürnberg

Hatice Öztürk · Friedrich-Alexander-Universität Erlangen-Nürnberg

Abstract

Immunological changes precede malignant transformation of OLP. Increased macrophage infiltration and M2 polarization was associated with the development of oral cancer in OLP. Macrophage infiltration could serve as predictive marker for malignant transformation.

Topics & Keywords

Oral Health Pathology and Treatment Head and Neck Cancer Studies Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

UN Sustainable Development Goals

Peace, Justice and strong institutions

Publication Details

Published in: Journal of Translational Medicine

Volume 18, Issue 1, pp. 11-11

DOI: 10.1186/s12967-019-02191-0

Field-Weighted Citation Impact: 7.51