NADPH protects against kainic acid-induced excitotoxicity via autophagy-lysosome pathway in rat striatum and primary cortical neurons

202028 citationsJournal Articlehybrid Open Access

Authors

Ziqi Liu · Soochow University

Na Liu · Soochow University

Sisi Huang · Soochow University

Miaomiao Lin · Soochow University

Shukui Qin · Soochow University

Junchao Wu · Soochow University

Zhong‐Qin Liang · Soochow University

Abstract

Our data provide a possible mechanism that NADPH ameliorates KA-induced excitotoxicity by blocking the autophagy-lysosome pathway and up-regulating TIGAR along with its antioxidant properties.

Topics & Keywords

Autophagy in Disease and Therapy Neuroinflammation and Neurodegeneration Mechanisms Neuroscience and Neuropharmacology Research

Publication Details

Published in: Toxicology

Volume 435, pp. 152408-152408

DOI: 10.1016/j.tox.2020.152408

Field-Weighted Citation Impact: 2.32

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NADPH protects against kainic acid-induced excitotoxicity via autophagy-lysosome pathway in rat striatum and primary cortical neurons

Authors

Abstract

Topics & Keywords

Publication Details