The threshold of alpha-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

2020243 citationsReviewgold Open Access

Authors

Jiaxin Zhang · Beijing University of Chinese Medicine

Guang Chen · Beijing University of Chinese Medicine

Peng Zhang · Beijing University of Chinese Medicine

Jiaying Zhang · Beijing University of Chinese Medicine

Xiaoke Li · Beijing University of Chinese Medicine

Danan Gan · Beijing University of Chinese Medicine

Xu Cao

Abstract

AFP levels in serum showed good accuracy in HCC diagnosis, and the threshold of AFP with 400 ng/mL was better than that of 200 ng/mL in terms of sensitivity and specificity no matter AFP is used alone or combined with ultrasound.

Topics & Keywords

Hepatocellular Carcinoma Treatment and Prognosis Liver Disease Diagnosis and Treatment Pancreatic and Hepatic Oncology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 15, Issue 2, pp. e0228857-e0228857

DOI: 10.1371/journal.pone.0228857

Field-Weighted Citation Impact: 19.36