Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment

2020374 citationsJournal Articlebronze Open Access

Authors

Anuja Sathe · Stanford Medicine

Susan M. Grimes · Palo Alto University

Billy T. Lau · Palo Alto University

Jiamin Chen · Stanford Medicine

Carlos J. Suarez · Stanford Medicine

Robert J. Huang · Stanford Medicine

George A. Poultsides ·

Abstract

Single-cell gene expression studies revealed widespread reprogramming across multiple cellular elements in the gastric cancer TME. Cellular remodeling was delineated by changes in cell numbers, transcriptional states, and intercellular interactions. This characterization facilitates understanding of tumor biology and enables identification of novel targets including for immunotherapy.

Topics & Keywords

Single-cell and spatial transcriptomics Immune cells in cancer Cancer Immunotherapy and Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 26, Issue 11, pp. 2640-2653

DOI: 10.1158/1078-0432.ccr-19-3231

Field-Weighted Citation Impact: 18.61