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GENERAL AND CLINICAL ASPECTS, RISK ASSESSMENT, AND GENOTOXICITY OF METALS Monitoring, Environmental, and Health Risk Assessments (Anna M. Fan) An Introduction to Monitoring and Environmental and Human Risk Assessment of Metals (Anna M. Fan) Monitoring and Assessment of Metal Contaminants in the Air (Josef M. Pacyna) Assessment of Ecological and Health Effects of Soil-Borne Trace Elements and Metals (A.C. Chang and A.L. Page) Assessment of Metals in Drinking Water With Specific References to Lead, Copper, Arsenic, and Selenium (Anna M. Fan) Risk Assessment of Metals (J. Michael Davis and Robert W. Elias) Techniques Employed for the Assessment of Metals in Biological System (Richard M. Jacob) Concepts on Biological Markers and Biomonitoring for Metal Toxicity (Lars Gerhardsson and Staffan Skerfving) Bioresponses and Reactivities to Metal Toxicity An Introduction to Bioresponses and Reactivities of Metals (Louis W. Chang) Determinants of Reactivity in Metal Toxicity (Evert Nieboer and Glenn G. Fletcher) Metals and Biological Membranes (Ernest C. Foulkes) Interactions Between Glutathione and Mercury in the Kidney, Liver, and Blood (Rudolfs K. Zalups and Lawrence H. Lash) The Role of General and Metal-Specific Cellular Responses in Protection and Repair of Metal-Induced Damage: Stress Proteins and Metallothioneins (Brenda M. Sanders, Peter L. Goering, and Kenneth Jenkins) Metal-Metal Interactions (Anada S. Prasad and Frances W. J. Beck) Carcinogenesis and Genotoxicity of Metals Part A: Carcinogenicity and Genotoxicity of Specific Metals An Introduction to Metal Toxicity and Carcinogenicity of Metals (Max Costa) Carcinogenicity and Genotoxicity of Chromium (Catherine B. Klein) The Carcinogenicity of Arsenic (Zaolin Wang and Toby G. Rossman) Cadmium Carcinogenicity and Genotoxicity (Michael P. Waalkes and R. Rita Misra) Mechanisms of Nickel Genotoxicity and Carcinogenicity (Max Costa) Carcinogenicity and Genotoxicity of Lead, Beryllium, and Other Metals (Mitchell D. Cohen, Darlene H. Bowser, and Max Costa) Part B: Selected Concepts in Metal Carcinogenesis An Introduction to Selected Concepts in Metal Carcinogenesis (Lionel A. Poirier) Metal Interactions in Chemical Carcinogenesis (Lionel A. Poirier and Neil A. Littlefield) Oxidative DNA Damage in Metal-Induced Carcinogenesis (Kazimierz S. Kasprzak) Metal-Induced Gene Expression and Neoplastic Transformation (Joseph R. Landolph, Michael Dews, Laurent Ozbun, and Douglas Parker Evans) Clinical Aspects of Metal Toxicity An Introduction to Clinical Aspects of Metal Toxicity (Kazuo T. Suzuki and Tsuguyoshi Suzuki) Minamata Disease and Other Mercury Syndromes (Rikuzo Hamada and Mitsuhiro Osame) Itai-Itai Disease and Health Effects of Cadmium (Koji Nagawa and Teruhiko Kido) Genetic Disorders of Copper Metabolism (Hiroko Kodama) Alzheimer's Disease and Other Aluminum-Associated Health Conditions (D.R. McLachlan, P.E. Fraser, E. Jaikaran, and W.J. Lukiw) Current Status of Childhood Lead Exposure at Low Dose (Herbert L. Needleman) Neurological Aspects in Human Exposure to Manganese (Naohide Inoue and Yuji Makita) Health Effects of Arsenic (Ganzalo G. Garcia-Vargas and Mariano E. Cebrian) Toxicity of Bismuth and Its Compounds (Anja Slikkerveer and Frederik A. de Wolff) Human Exposure to Lithium, Thallium, Antimony, Gold, and Platinum (G.B. van der Voet and Frederik A. de Wolff) Cobalt and Nickel Induced Hard Metal Asthma (Yukinori Kusaka) Aspects on Health Risks of Mercury from Dental Amalgams (Jan A. Weiner and Magnus Nylander) Chelation Therapies for Metal Intoxication (Carol R. Angle)