LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

202075 citationsJournal Articlegold Open Access

Authors

Yahya Sohrabi · University Hospital Münster

G. Sonntag · University Hospital Münster

Laura C. Braun · University Hospital Münster

Sina M. M. Lagache · University Hospital Münster

Marie Liebmann · University Hospital Münster

Luisa Klotz · University Hospital Münster

Rinesh Godfrey

Abstract

We demonstrate that LXR activation induces a proinflammatory trained immunity phenotype in human monocytes through epigenetic and metabolic reprogramming. Our data reveal important novel aspects of LXR signaling in innate immunity.

Topics & Keywords

Immune responses and vaccinations Birth, Development, and Health Diabetes and associated disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 11, pp. 353-353

DOI: 10.3389/fimmu.2020.00353

Field-Weighted Citation Impact: 3.72