Pain due to Ehlers-Danlos Syndrome Is Associated with Deficit of the Endogenous Pain Inhibitory Control

202032 citationsJournal Article

Authors

Caterina Leone · Sapienza University of Rome

Claudia Celletti · Sapienza University of Rome

Gianfranco Gaudiano · Sapienza University of Rome

Paola Anna Puglisi · Sapienza University of Rome

Alessandra Fasolino · Sapienza University of Rome

G. Cruccu · Sapienza University of Rome

Filippo Camerota

Abstract

Our psychophysical study showing that patients with pain due to hEDS have an increased wind-up ratio in the area of maximum pain and abnormal CPM protocol suggests that in this condition, pain is associated with central sensitization, possibly due to deficit of the endogenous pain inhibitory control. These data might be relevant to pharmacological treatment.

Topics & Keywords

Botulinum Toxin and Related Neurological Disorders Pain Mechanisms and Treatments Connective tissue disorders research

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Pain Medicine

Volume 21, Issue 9, pp. 1929-1935

DOI: 10.1093/pm/pnaa038

Field-Weighted Citation Impact: 1.88