How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

202075 citationsReviewbronze Open Access

Authors

Sajad Yaghoubi · Iranshahr University

Hamid Najminejad · Shahid Sadoughi University of Medical Sciences and Health Services

Mehran Dabaghian · Razi Vaccine and Serum Research Institute

Mohammad Hossein Karimi · Shiraz University of Medical Sciences

Meghdad Abdollahpour‐Alitappeh · Islamic Azad University, Larestan Branch

Fariba Rad · High Institute for Education and Research in Transfusion Medicine

Abstract

Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell-derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.

Topics & Keywords

Extracellular vesicles in disease MicroRNA in disease regulation Autophagy in Disease and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: IUBMB Life

Volume 72, Issue 7, pp. 1286-1305

DOI: 10.1002/iub.2275

Field-Weighted Citation Impact: 3.25