Single‐cell RNA sequencing analysis of human kidney reveals the presence of ACE2 receptor: A potential pathway of COVID‐19 infection

202049 citationsJournal Articlegold Open Access

Authors

Qiyu He · First Affiliated Hospital of Jinan University

Tsz Ngai Mok · First Affiliated Hospital of Jinan University

Yun Liang · Southern Medical University

Chengbo He · Guangzhou Electronic Technology (China)

Jieruo Li · First Affiliated Hospital of Jinan University

Jinghua Pan · First Affiliated Hospital of Jinan University

Abstract

Our study provided the cellular evidence that SARS-Cov-2 invaded human kidney tissue via proximal convoluted tubule, proximal tubule, proximal straight tubule cells, and glomerular parietal cells by means of ACE2-related pathway and used their cellular protease TMPRSS2 for priming.

Topics & Keywords

SARS-CoV-2 and COVID-19 Research COVID-19 Clinical Research Studies Long-Term Effects of COVID-19

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Genetics & Genomic Medicine

Volume 8, Issue 10, pp. e1442-e1442

DOI: 10.1002/mgg3.1442

Field-Weighted Citation Impact: 0.95