Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets

2020122 citationsJournal Articlebronze Open Access

Authors

Yanyan Xu · Ministry of Education

Haojie Jiang · Ministry of Education

Li Li · Huazhong University of Science and Technology

Fengwu Chen · Soochow University

Yunxia Liu · Ministry of Education

Meiyi Zhou · Ministry of Education

Ji Wang ·

Abstract

BCAA catabolism is an important regulator of platelet activation and is associated with arterial thrombosis risk. Targeting the BCAA catabolism pathway or lowering dietary BCAA intake may serve as a novel therapeutic strategy for metabolic syndrome-associated thrombophilia.

Topics & Keywords

Metabolomics and Mass Spectrometry Studies Muscle metabolism and nutrition Advanced Proteomics Techniques and Applications

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Circulation

Volume 142, Issue 1, pp. 49-64

DOI: 10.1161/circulationaha.119.043581

Field-Weighted Citation Impact: 5.42