Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease

2020177 citationsJournal Articlebronze Open Access

Authors

Nilaksh Gupta · Cleveland Clinic Lerner College of Medicine

Jennifer A. Buffa · Cleveland Clinic Lerner College of Medicine

Adam Roberts · Cleveland Clinic

Naseer Sangwan · Cleveland Clinic Lerner College of Medicine

Sarah M. Skye · Cleveland Clinic Lerner College of Medicine

Lin Li · Cleveland Clinic

Karen J. Ho

Abstract

Selective targeting of gut microbiota-dependent TMAO generation may prevent adverse renal structural and functional alterations in subjects at risk for chronic kidney disease.

Topics & Keywords

Gut microbiota and health Gastroesophageal reflux and treatments Gastrointestinal motility and disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 40, Issue 5, pp. 1239-1255

DOI: 10.1161/atvbaha.120.314139

Field-Weighted Citation Impact: 9.18