Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression

2020223 citationsJournal Articlegold Open Access

Authors

Qing Liu · Zhongnan Hospital of Wuhan University

Chaogang Yang · Wuhan Donghu University

Shuyi Wang · Hubei Cancer Hospital

Dongdong Shi · Hubei Cancer Hospital

Wei Chen · Zhongnan Hospital of Wuhan University

Jialin Song · Wuhan Donghu University

Xiaobin Lin ·

Abstract

Our data indicate that Wnt5a could induce M2 polarization of TAMs by regulating CaKMII-ERK1/2-STAT3 pathway-mediated IL-10 secretion, ultimately promoting tumor growth and metastasis of CRC.

Topics & Keywords

Immune cells in cancer Epigenetics and DNA Methylation Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cell Communication and Signaling

Volume 18, Issue 1, pp. 51-51

DOI: 10.1186/s12964-020-00557-2

Field-Weighted Citation Impact: 7.80