The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer

2020518 citationsJournal Articlegold Open Access

Authors

Xiaying Zheng · Chongqing Medical University

Mengge Huang · Sun Yat-sen University

Lei Xing · First Affiliated Hospital of Chongqing Medical University

Rui Yang · Chongqing Medical University

Xiaosong Wang · Chongqing Medical University

Rong Jiang · Chongqing Medical University

Luyu Zhang

Abstract

Our data reveal that the circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer through circSEPT9/miR-637/LIF axis. Therefore, circSEPT9 could be used as a potential prognostic marker and therapeutical target for TNBC.

Topics & Keywords

Circular RNAs in diseases MicroRNA in disease regulation Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Cancer

Volume 19, Issue 1, pp. 73-73

DOI: 10.1186/s12943-020-01183-9

Field-Weighted Citation Impact: 32.53