Continuous chromosome-scale haplotypes assembled from a single interspecies F1 hybrid of yak and cattle

202099 citationsJournal Articlegold Open Access

Authors

Edward S. Rice · University of Nebraska–Lincoln

Sergey Koren · National Human Genome Research Institute

Arang Rhie · National Human Genome Research Institute

Michael P. Heaton · Roman L. Hruska U.S. Meat Animal Research Center

Ted Kalbfleisch · University of Kentucky

Timothy Hardy · Lawrence Livermore National Security

Peter H. Hackett

Abstract

The high heterozygosity inherent to interspecies crosses maximizes the effectiveness of the trio binning method. The interspecies trio binning approach we describe is likely to provide the highest-quality assemblies for any pair of species that can interbreed to produce hybrid offspring that develop to sufficient cell numbers for DNA extraction.

Topics & Keywords

Chromosomal and Genetic Variations Genetic Mapping and Diversity in Plants and Animals Genomics and Phylogenetic Studies

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: GigaScience

Volume 9, Issue 4

DOI: 10.1093/gigascience/giaa029

Field-Weighted Citation Impact: 14.37