CD38 Antibody Daratumumab for the Treatment of Chronic Active Antibody-mediated Kidney Allograft Rejection

2020112 citationsJournal Article

Authors

Konstantin Doberer · Medical University of Vienna

Johannes Kläger · Medical University of Vienna

Guido A. Gualdoni · Medical University of Vienna

Katharina A. Mayer · Medical University of Vienna

Farsad Eskandary · Medical University of Vienna

Evan A. Farkash

Hermine Agis · Medical University of Vienna

Abstract

Targeting CD38 for plasma cell and NK cell depletion may be an effective strategy to counteract AMR. Our results may encourage the design of future trials to clarify the role of this innovative treatment concept in organ transplantation.

Topics & Keywords

Renal Transplantation Outcomes and Treatments Cytomegalovirus and herpesvirus research Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Transplantation

Volume 105, Issue 2, pp. 451-457

DOI: 10.1097/tp.0000000000003247

Field-Weighted Citation Impact: 12.23