m6A-dependent glycolysis enhances colorectal cancer progression

2020447 citationsJournal Articlegold Open Access

Authors

Chaoqin Shen · State Key Laboratory of Oncogene and Related Genes

Baoqin Xuan · Shanghai Cancer Institute

Tingting Yan · Shanghai Cancer Institute

Yanru Ma · Renji Hospital

Pingping Xu · Shanghai Institute of Hematology

Xianglong Tian · Shanghai Jiao Tong University

Xinyu Zhang

Abstract

METTL3 is a functional and clinical oncogene in CRC. METTL3 stabilizes HK2 and SLC2A1 (GLUT1) expression in CRC through an m<sup>6</sup>A-IGF2BP2/3- dependent mechanism. Targeting METTL3 and its pathway offer alternative rational therapeutic targets in CRC patients with high glucose metabolism.

Topics & Keywords

RNA modifications and cancer Cancer-related molecular mechanisms research Cancer-related gene regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Cancer

Volume 19, Issue 1, pp. 72-72

DOI: 10.1186/s12943-020-01190-w

Field-Weighted Citation Impact: 24.92