Hippocampal Interictal Spikes during Sleep Impact Long‐Term Memory Consolidation

202063 citationsJournal Article

Authors

Isabelle Lambert · Hôpital de la Timone

E. Tramoni-Negre · Inserm

Stanislas Lagarde · Hôpital de la Timone

Nicolas Roehri · Inserm

Bernard Giusiano · Inserm

Agnès Trébuchon-Da Fonseca · Inserm

Romain Carron · Institut de Neurosciences des Systèmes

Abstract

Our results show that activation of interictal spikes in the hippocampus during sleep and seizures specifically impair long-term memory consolidation. We hypothesize that hippocampal interictal spikes during sleep interrupt hippocampal-neocortical transfer of information. ANN NEUROL 2020;87:976-987.

Topics & Keywords

Sleep and Wakefulness Research Neuroscience and Neuropharmacology Research Memory and Neural Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 87, Issue 6, pp. 976-987

DOI: 10.1002/ana.25744

Field-Weighted Citation Impact: 3.97