Thiamethoxam, a Neonicotinoid Poisoning Causing Acute Kidney Injury via a Novel Mechanism

Human self-poisoning with insecticides is common in every part of the world because of their easy availability, and more so among farming households. Commonly used insecticides for this purpose are organophosphates and carbamates. Due to the high human toxicity of these agents, newer agents called neonicotinoids have been invented, which are relatively more toxic to insects and less toxic to humans and other mammals, partly because of their lesser interaction with vertebrate's nicotinic receptors and the inability to penetrate the mammalian blood−brain barrier.