Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial

2020197 citationsJournal Articlebronze Open Access

Authors

Cynthia Sharpe · Rady Children's Hospital-San Diego

Gail Reiner · Rady Children's Hospital-San Diego

Suzanne L. Davis · Starship Children's Health

Mark Nespeca · University of California, San Diego

Jeffrey J. Gold · University of California, San Diego

Maynard R. Rasmussen

Rachel Kuperman · UCSF Benioff Children's Hospital

Abstract

In this phase IIb study, phenobarbital was more effective than levetiracetam for the treatment of neonatal seizures. Higher rates of adverse effects were seen with phenobarbital treatment. Higher-dose studies of levetiracetam are warranted, and definitive studies with long-term outcome measures are needed.

Topics & Keywords

Neonatal and fetal brain pathology Epilepsy research and treatment Neonatal Respiratory Health Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PEDIATRICS

Volume 145, Issue 6

DOI: 10.1542/peds.2019-3182

Field-Weighted Citation Impact: 38.20