A human monoclonal antibody blocking SARS-CoV-2 infection

20201,150 citationsJournal Articlegold Open Access

Authors

Chunyan Wang · Utrecht University

Wentao Li · Utrecht University

Dubravka Drabek · Erasmus MC

Nisreen M.A. Okba · Erasmus MC

Rien van Haperen · Erasmus MC

Albert D. M. E. Osterhaus · University of Veterinary Medicine Hannover, Foundation

Frank J. M. van Kuppeveld ·

Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

Topics & Keywords

SARS-CoV-2 and COVID-19 Research vaccines and immunoinformatics approaches Animal Virus Infections Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Nature Communications

Volume 11, Issue 1, pp. 2251-2251

DOI: 10.1038/s41467-020-16256-y

Field-Weighted Citation Impact: 27.76