Sensitivity in Detection of Antibodies to Nucleocapsid and Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Coronavirus Disease 2019

2020406 citationsJournal Articlehybrid Open Access

Authors

Peter D. Burbelo · National Institute of Dental and Craniofacial Research

Francis X. Riedo · Evergreen Health Medical Center

Chihiro Morishima · University of Washington

Stephen A. Rawlings · University of California, San Diego

Davey M. Smith · University of California, San Diego

Sanchita Das · National Institutes of Health Clinical Center

Jeffrey R. Strich

Abstract

Antibody to the nucleocapsid protein of SARS-CoV-2 is more sensitive than spike protein antibody for detecting early infection. Analyzing heat-inactivated samples with a luciferase immunoprecipitation system assay is a safe and sensitive method for detecting SARS-CoV-2 antibodies.

Topics & Keywords

SARS-CoV-2 and COVID-19 Research SARS-CoV-2 detection and testing COVID-19 Clinical Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 222, Issue 2, pp. 206-213

DOI: 10.1093/infdis/jiaa273

Field-Weighted Citation Impact: 8.74