Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

2020249 citationsJournal Articlehybrid Open Access

Authors

Koen Veys · VIB-KU Leuven Center for Cancer Biology

Zheng Fan · Department of Medical Sciences

Moheb Ghobrial · University of Zurich

Ann Bouché · VIB-KU Leuven Center for Cancer Biology

Melissa García‐Caballero · VIB-KU Leuven Center for Cancer Biology

Kim Vriens · VIB-KU Leuven Center for Cancer Biology

Nadine V. Conchinha

Abstract

GLUT1 is the main glucose transporter in ECs and becomes uncoupled from glycolysis during quiescence in a Notch-dependent manner. It is crucial for developmental CNS angiogenesis and adult CNS homeostasis but does not affect BBB barrier function.

Topics & Keywords

Diet and metabolism studies Metabolism, Diabetes, and Cancer Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Circulation Research

Volume 127, Issue 4, pp. 466-482

DOI: 10.1161/circresaha.119.316463

Field-Weighted Citation Impact: 12.31