A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

2020232 citationsJournal Articlebronze Open Access

Authors

Jean‐Laurent Casanova · Howard Hughes Medical Institute

Helen C. Su · National Institutes of Health

Stéphanie Boisson‐Dupuis

Abstract

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.

Topics & Keywords

SARS-CoV-2 and COVID-19 Research Immune responses and vaccinations interferon and immune responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cell

Volume 181, Issue 6, pp. 1194-1199

DOI: 10.1016/j.cell.2020.05.016

Field-Weighted Citation Impact: 5.24