Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice

202066 citationsJournal Articlebronze Open Access

Authors

Gaolin Qiu · Anhui Medical University

Ying Wu · Shanghai Jiao Tong University

Zeyong Yang · Chinese Institute for Brain Research

Long Li · Anhui Provincial Hospital

Xiaona Zhu · Anhui Medical University

Yiqiao Wang · Anhui Provincial Hospital

Wenzhi Sun ·

Abstract

Dexmedetomidine activates dopamine neurons in the ventral tegmental area and increases dopamine concentrations in the related forebrain projection areas. This mechanism may explain rapid arousability upon dexmedetomidine sedation.

Topics & Keywords

Neuroscience and Neuropharmacology Research Memory and Neural Mechanisms Anesthesia and Sedative Agents

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesiology

Volume 133, Issue 2, pp. 377-392

DOI: 10.1097/aln.0000000000003347

Field-Weighted Citation Impact: 4.16