In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET

2020286 citationsJournal Articlehybrid Open Access

Authors

Adam P. Mecca · Yale University

Ming‐Kai Chen · Yale University

Ryan S. O’Dell · Yale University

Mika Naganawa · Yale University

Takuya Toyonaga · Yale University

Tyler A. Godek · Yale University

Joanna E. Harris · Yale University

Abstract

We were able to measure widespread synaptic loss due to AD using [<sup>11</sup> C]UCB-J PET. Future studies will continue to evaluate the utility of SV2A PET for tracking AD progression and for monitoring potential therapies.

Topics & Keywords

Alzheimer's disease research and treatments Functional Brain Connectivity Studies Mitochondrial Function and Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 16, Issue 7, pp. 974-982

DOI: 10.1002/alz.12097

Field-Weighted Citation Impact: 20.76