Transcriptional and Cellular Diversity of the Human Heart

2020562 citationsJournal Articlebronze Open Access

Authors

Nathan R. Tucker · Massachusetts General Hospital

Mark Chaffin · Anna Needs Neuroblastoma Answers

Stephen J. Fleming · BC Platforms (Finland)

Amelia Weber Hall · Massachusetts General Hospital

Victoria A. Parsons · Parsons (United States)

Kenneth Bedi · University of Pennsylvania

Amer-Denis Akkad

Abstract

Using large-scale single nuclei RNA sequencing, we defined the transcriptional and cellular diversity in the normal human heart. Our identification of discrete cell subtypes and differentially expressed genes within the heart will ultimately facilitate the development of new therapeutics for cardiovascular diseases.

Topics & Keywords

Congenital heart defects research Cardiac Fibrosis and Remodeling Single-cell and spatial transcriptomics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 142, Issue 5, pp. 466-482

DOI: 10.1161/circulationaha.119.045401

Field-Weighted Citation Impact: 30.69