Aneuploidy in targeted endoscopic biopsies outperforms other tissue biomarkers in the prediction of histologic progression of Barrett's oesophagus: A multi-centre prospective cohort study

202026 citationsJournal Articlegold Open Access

Authors

Andreas V. Hadjinicolaou · University of Cambridge

Sanne N. van Munster · University of Amsterdam

Achilleas Achilleos · University of Cambridge

José Santiago García · NIHR Nottingham Digestive Diseases Biomedical Research Unit

Sarah Killcoyne · European Bioinformatics Institute

Krish Ragunath · NIHR Nottingham Digestive Diseases Biomedical Research Unit

Jacques Bergman

Abstract

Aneuploidy is the only biomarker that predicts neoplastic progression of NDBO. Aberrant p53 expression suggests prevalent dysplasia, which might have been missed by random biopsies, and warrants early follow up.

Topics & Keywords

Esophageal Cancer Research and Treatment Gastric Cancer Management and Outcomes Esophageal and GI Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: EBioMedicine

Volume 56, pp. 102765-102765

DOI: 10.1016/j.ebiom.2020.102765

Field-Weighted Citation Impact: 4.08