Adipose mesenchymal stem cell transplantation alleviates spinal cord injury-induced neuroinflammation partly by suppressing the Jagged1/Notch pathway

202067 citationsJournal Articlegold Open Access

Authors

Zhilai Zhou · Guangdong Provincial People's Hospital

Xiaobo Tian · Guangdong Provincial People's Hospital

Mo Biling · Guangzhou Liwan District Traditional Chinese Medicine Hospital

Huali Xu · Southern Medical University

Li Zhang · Guangdong Provincial People's Hospital

Lishan Huang · Guangdong Provincial People's Hospital

Shun Yao

Abstract

The results of this study demonstrated that the therapeutic effects of ADSCs in SCI mice were partly due to Jagged1/Notch signaling pathway inhibition and a subsequent reduction in JAK/STAT3 phosphorylation in astrocytes.

Topics & Keywords

Spinal Cord Injury Research Mesenchymal stem cell research Neurogenesis and neuroplasticity mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 11, Issue 1, pp. 212-212

DOI: 10.1186/s13287-020-01724-5

Field-Weighted Citation Impact: 6.09