A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ ₄₂ and tau‐induced pathophysiological effects on long‐term potentiation

In this study, by combining multiple relevant and important molecular and technical aspects of neuroscience research, we generated a new, fully human in vitro system to model and study AD at the preclinical stage. This system can serve as a novel drug discovery platform to identify compounds that rescue or alleviate the initial neuronal deficits caused by Aβ₄₂ and/or tau oligomers, a main focus of clinical trials.