Distinguishing Extravascular from Intravascular Ferumoxytol Pools within the Brain: Proof of Concept in Patients with Treated Glioblastoma

202014 citationsJournal Articlehybrid Open Access

Authors

Ramon Barajas · Cancer Institute (WIA)

Daniel L. Schwartz · Advanced Imaging Research (United States)

Heather McConnell · United States Nuclear Regulatory Commission

Cymon Kersch · United States Nuclear Regulatory Commission

Xin Li · Advanced Imaging Research (United States)

Bronwyn E. Hamilton · Jisc

Jay Starkey

Abstract

Segregation and extravascular localization of ferumoxytol MR imaging improves on current techniques by eliminating intrinsic tissue and intravascular ferumoxytol signal and may inform glioblastoma outcomes by serving as a more specific metric of macrophage content compared with uncorrected T1 and SWI techniques.

Topics & Keywords

Glioma Diagnosis and Treatment MRI in cancer diagnosis Radiomics and Machine Learning in Medical Imaging

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Neuroradiology

Volume 41, Issue 7, pp. 1193-1200

DOI: 10.3174/ajnr.a6600

Field-Weighted Citation Impact: 1.03