The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers

202052 citationsJournal Articlegold Open Access

Authors

Jing Chen · First Hospital of China Medical University

Xu Zhao · Liaoning Vocational College of Medical

Yuan Yuan · First Hospital of China Medical University

Jingjing Jing · First Hospital of China Medical University

Abstract

Members of PTPN family were differentially expressed in digestive tract cancers. Correlations were found between PTPN genes and clinicopathological parameters of patients. Expression of PTPN12 was upregulated in both STAD and CRC, and thus could be used as a diagnostic biomarker. Differential expression of PTPN12 in GC and CRC, and PTPN22 in CRC were presented in our histological verification experiment.

Topics & Keywords

Protein Tyrosine Phosphatases RNA modifications and cancer Galectins and Cancer Biology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Cell International

Volume 20, Issue 1, pp. 238-238

DOI: 10.1186/s12935-020-01315-7

Field-Weighted Citation Impact: 2.34