Effects of Allopurinol on the Progression of Chronic Kidney Disease

2020440 citationsJournal Articlebronze Open Access

Authors

Sunil V. Badve · The University of Queensland

Elaine M. Pascoe · The University of Queensland

Anushree Tiku · St Vincent Hospital

Neil Boudville · The University of Queensland

Fiona G. Brown · St Vincent Hospital

Alan Cass · St Vincent Hospital

Philip Clarke ·

Abstract

In patients with chronic kidney disease and a high risk of progression, urate-lowering treatment with allopurinol did not slow the decline in eGFR as compared with placebo. (Funded by the National Health and Medical Research Council of Australia and the Health Research Council of New Zealand; CKD-FIX Australian New Zealand Clinical Trials Registry number, ACTRN12611000791932.).

Topics & Keywords

Gout, Hyperuricemia, Uric Acid Pharmacological Effects of Natural Compounds Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 382, Issue 26, pp. 2504-2513

DOI: 10.1056/nejmoa1915833

Field-Weighted Citation Impact: 37.77