Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus

202062 citationsJournal Articlegold Open Access

Authors

Haruyo Yagi · University of Pittsburgh

Antonia F. Chen · Brigham and Women's Hospital

David Hirsch · University of Pittsburgh

Adam C. Rothenberg · University of Pittsburgh

Jian Tan · University of Pittsburgh

Peter G. Alexander · University of Pittsburgh

Rocky S. Tuan ·

Abstract

Our findings clearly demonstrate the antimicrobial activity of adult ASCs against S. aureus and implicate a key regulatory role for vitamin D. Further testing in in vivo models is being pursued to assess the potential application of ASCs as a biocompatible, adjunct treatment for musculoskeletal infections.

Topics & Keywords

Orthopedic Infections and Treatments Mesenchymal stem cell research Wound Healing and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 11, Issue 1, pp. 293-293

DOI: 10.1186/s13287-020-01807-3

Field-Weighted Citation Impact: 7.36