Quantifying the effects of quadrupolar sinksvia15N relaxation dynamics in metronidazoles hyperpolarizedviaSABRE-SHEATH

202048 citationsJournal Articlegreen Open Access

Authors

Jonathan R. Birchall · Wayne State University

Mohammad Shah Hafez Kabir · Wayne State University

Oleg G. Salnikov · Novosibirsk State University

Nikita V. Chukanov · Novosibirsk State University

Alexandra Svyatova · Novosibirsk State University

Kirill V. Kovtunov · Novosibirsk State University

Igor V. Koptyug

Abstract

15N spin-lattice relaxation dynamics in metronidazole-15N3 and metronidazole-15N2 isotopologues are studied for rational design of 15N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14N nucleus within the spin-relayed 15N-15N network.

Topics & Keywords

Advanced NMR Techniques and Applications Solid-state spectroscopy and crystallography Electron Spin Resonance Studies

Publication Details

Published in: Chemical Communications

Volume 56, Issue 64, pp. 9098-9101

DOI: 10.1039/d0cc03994b

Field-Weighted Citation Impact: 3.49

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Quantifying the effects of quadrupolar sinks<i>via</i><sup>15</sup>N relaxation dynamics in metronidazoles hyperpolarized<i>via</i>SABRE-SHEATH

Authors

Abstract

Topics & Keywords

Publication Details