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Nowadays, it is an obvious fact that it is necessary to look for new approaches to agriculture, which would ensure the maximum reduction in the dependence of the volumes and quality of the crop on external factors. The use of nanopreparations in crop production is the most promising. The development of new technologies and techniques using nanomaterials, which would ensure high yields and quality of potato products, is relevant and has great practical importance. The research in recent years has established the important role of selenium in the regulation of plant activity.The purpose of this work was to research the effect of selenium nanoparticles and selenium in the form of micronutrient fertilizers on early-maturing varieties of potatoes for table use: adaptive capacity and nutritional value. Selenium nanopowder in the form of a solution contained the optimum nanoselenium concentration applied–0.13 g per hectare seeding rate. The potato tubers were soaked in distilled water 30 minutes before seeding. The treatment of potato tubers with selenium micronutrient, the dose of which amounted to 400 g per 1 hectare, was also carried out before planting. The soil preparation and agrotechnology cultivation generally accepted in the Ryazan region.The research results showed that presowing treatment of potato tubers with selenium nanopreparation had the most favorable effect on the adaptive capacity of plants (heat resistance, water-holding properties), as well as on yield increase, than treatment of tubers with selenium in the form of microfertilizer. The use of Se nanoparticles leads to an increase in the protein and vitamin C content. The Udacha potato variety showed great responsiveness to the entering of various forms of selenium in comparison with others. The use of selenium in the form of microfertilizer leads to an increase in the accumulation of starch and dry matter. These figures were the highest in potato tubers of the Zhukovskiy Ranniy variety.