Age‐related decline of interferon‐gamma responses in macrophage impairs satellite cell proliferation and regeneration

2020103 citationsJournal Articlegold Open Access

Authors

Congcong Zhang · Capital Medical University

Naixuan Cheng · Capital Medical University

Bokang Qiao · Capital Medical University

Fan Zhang · Capital Medical University

Jian Wu · Capital University of Physical Education and Sports

Chang Liu · Capital Medical University

Yulin Li ·

Abstract

Our study indicates that decline in IFN-γ response in a novel subset of macrophage contributes to satellite cells dysfunctions in aged skeletal muscles and demonstrates that this mechanism can be targeted to restore age-associated myogenesis.

Topics & Keywords

Muscle Physiology and Disorders Prosthetics and Rehabilitation Robotics Exercise and Physiological Responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Cachexia Sarcopenia and Muscle

Volume 11, Issue 5, pp. 1291-1305

DOI: 10.1002/jcsm.12584

Field-Weighted Citation Impact: 4.85

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