Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture

202037 citationsJournal Articlehybrid Open Access

Authors

Tomáš Vaisar · University of Washington

Jie Hu · University of Washington

Nathan Airhart · University of Washington

Kate Fox · University of Washington

Jay W. Heinecke · University of Washington

Roberto F. Nicosia · University of Washington

Ted R. Kohler ·

Abstract

Parallel studies of SR-uPA<sup>+/0</sup> mouse aortas and human plaques identify mechanisms that connect proteolysis with plaque rupture, including inflammation, basement-membrane protein loss, and apoptosis. Basement-membrane protein loss is a prominent feature of ruptured human plaques, suggesting a major role for basement-membrane proteins in maintaining plaque stability.

Topics & Keywords

Protease and Inhibitor Mechanisms Atherosclerosis and Cardiovascular Diseases Advanced Proteomics Techniques and Applications

Publication Details

Published in: Circulation Research

Volume 127, Issue 8, pp. 997-1022

DOI: 10.1161/circresaha.120.317295

Field-Weighted Citation Impact: 1.20

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Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture

Authors

Abstract

Topics & Keywords

Publication Details